Find the cheapest buses from Santa Cruz to Santiago

Looking for cheap tickets from Santa Cruz to Santiago? FlixBus has you covered. The distance between Santa Cruz and Santiago is 164 km, which takes a minimum of 2 hours 24 minutes.
FlixBus has a large network, so you can travel onwards with us once you reach Santiago.

So how to find the best ticket prices? Be sure to book in advance on our website or via our FlixBus App. When booking through the App, your ticket will be stored directly, making bus travel even more green and convenient!

Taking the bus from Santa Cruz

Santa Cruz is well-connected on the FlixBus network with 4 connections departing every day from the city bus station, making it very easy to travel across the country.

Arrival in Santiago

With 6 bus stations, Santiago is well-connected. Traveling with FlixBus around the country is very cheap and easy, as to get to Santiago you can pick one of the 51 routes arriving daily.

What to expect onboard the FlixBus bus from Santa Cruz to Santiago

Once you’ve booked your bus tickets through the FlixBus App using one of our secure payment methods, you just need to bring your phone to use as your ticket - and your luggage, of course. Don’t worry about packing light as you can bring one piece of carry-on luggage and one piece of hold luggage for your journey.

Want to be guaranteed the best seat in the house? You can choose yours when you book your ticket. Opt for a classic seat, a table seat, a panorama seat for a great view, or reserve the free seat beside you for extra space.

Once you’ve stowed your luggage away and settled in, sit back and enjoy the journey with the onboard services on your FlixBus bus including free Wi-Fi onboard, FLIXtainment - our entertainment portal, toilets and plug socket.Whether you need to fire off some emails during your trip, or you want to relax and enjoy the ride, we’ve got you covered.